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Endocrine Disorders

Updated

12/2/2016

Other Names Congenital Adrenal Hyperplasia (CAH); Congenital Hypothyroidism (CH); Thyroxine (T4); Thyroid Stimulating Hormone (TSH); Newborn screening 
How to Order
This test is part of the Newborn Screening Panel. Submit Newborn Screening Dried Blood Spot Specimen Collection Card
Availability
Birthing centers, medical practitioners and laboratories responsible for newborn screening specimen collection.
Methodology
Fluorometric immunoassay for 17-hydroxyprogesterone (17-OHP) for CAH; Thyroxine (T4) and Thyroid Stimulating Hormone (TSH) for CH.
Performed
This test is part of the Newborn Screening Panel. Submit Newborn Screening Dried Blood Spot Specimen Collection Card
Time to Reporting
2 to 7 working days after receipt of specimen collection card for first specimens.
2 to 10 working days after receipt of specimen collection card for subsequent specimens.
CPT Code
83498 – Hydroxyprogesterone, 17-d

 

84437 – Thyroxine; total, requiring elution (eg, neonatal)

84443 – Thyroid stimulating hormone (TSH)



Specimen Collection Details

Collection
Capillary blood obtained from heel lance and applied to newborn screening filter paper circles on the specimen collection card. Obtain specimen prior to transfusion. Demographic fields should be filled in completely. Routine first screening specimen should be collected at 24-48 hours of age or before discharge; routine second screening specimen should be collected at 10-15 days of age.
Collection instructions are different for NICU/SCN infants. Refer to hospital procedures and the Newborn Screening Program Practitioners' Manual for details.
Optimal Volume
Four evenly saturated 0.5 inch circles.
Minimum Volume
Two evenly saturated 0.5 inch circles.
Handling
Air-dry specimens at room temperature for  a minimum of 3 hours in a horizontal position.  Insert dried specimens into a paper, cardboard or Tyvek envelope (do not use plastic) for shipping.  Specimens collected on weekends or holidays should be stored at room temperature and sent by overnight mail or courier at the earliest opportunity. Avoid exposing specimen to excess temperatures or humidity.
Transport
All specimens should be sent overnight mail or by courier within 24 hours of collection.
Rejection Criteria
Improperly collected specimens, including: uneven saturation, insufficient blood volume, contamination, specimen received more than 14 days after collection or infant is older than 6 months of age.
Comments
For more information visit Oregon's Newborn Screening Practitioner's Manual at public.health.oregon.gov/LaboratoryServices/NewbornScreening/Documents/nbspract/manual.pdf